Mesothelioma of the pleura.
نویسنده
چکیده
Wagner’ in Germany in 1870 was the first to describe a tumor with the characteristics of a pleural mesothelioma and to recognize it as a pathological entity. He called it “a tubercle-like lymph adenoma.” From the time of this first description there has been a controversy among medical authorities until recently relative to the origin, histology and nomenclature of this dIsease. It has been variously called pleural carcinoma, mesothelioma, endothellal carcinoma, mesothelial carcinoma, endothelioma, carcinomatodes, adeno endothelioma, sarco endothelioma, perithelioma, lymphanglo endothelioma, fibro endotheliosis of pleura, lymphangltis proliferans and Cornil2 and his co-workers in France have suggested the name, pleuroma. Although there have been many opinions, some authors even denying the existence of a primary pleural neoplasm, the names have narrowed down until the most common ones in use are: 1) Endothelioma, by those who believe the tumor originates from the endothelium of the pleural lymphatics and 2) Mesothelioma, by those who maintain the tumor originates from the lining epithelium of the pleura, since the latter are derived from the mesoderm in the embryo. Ewing3 as late as 1940 states: “It is possible that two groups of serous endotheliomas should be recognized, one Invasive with metastases and derived from the endothellum of the lymph spaces and another superficial, nodular or papillary, and originating from the lining cells.” The confusing elements in the tumor seemed to be the mixture of epithelial appearing cells and connective tissue. The epithelial appearing cells at times arrange themselves as, and take on, glandular characteristics. The connective tissue stroma varies in amount and density and shows areas of hyalinlzation. How could a cell which is primarily epithelial in nature take on glandular and connective tissue elements? Maximow4 demonstrated in 1927 that the covering cells of the serosal surfaces are pleomorphic and when cultured outside the body, In vitro, assume a fibroblastic nature and form collagen fibres. Twenty years later Maximow and Bloom5 stated, “The mesothelium is a simple, squamous cell layer which covers the
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عنوان ژورنال:
- Diseases of the chest
دوره 17 5 شماره
صفحات -
تاریخ انتشار 1950